ABSTRACT
ABSTRACT Introduction: Anemia is a common issue in surgical patients and has been associated with worse clinical outcomes, such as a higher probability of transfusions and longer hospital stay. Therefore, Patient Blood Management programs are actively aiming to achieve early identification and treatment of anemia, previous to the surgery. Methods and materials: In this study, preoperative hemoglobin within the Blood Order Schedule (BOS) at 16 blood centers in several Brazilian regions were retrospectively evaluated. Data regarding hemoglobin, age, gender and Brazilian regions were further analyzed. Results: From the 20,201 BOSs evaluated, the mean age was 55.65 ± 23.52 years old, with an overall prevalence of preoperative anemia of 60.9%. Women had a lower mean preoperative hemoglobin (11.74 ± 2.84 for women and 12.27 ± 3.06 for men) and higher prevalence of anemia than men (66% of females and 52.2% of males). The individuals over 65 years old and under 18 were the most affected by preoperative anemia. All regions had a high prevalence of preoperative anemia, without any direct association with the Human Development Index. Conclusion: In summary, upon evaluating the BOS, our study showed a high prevalence of preoperative anemia in all Brazilian regions, regardless of the gender and age group, but that women and individuals less than 18 or over 65 years old have an even higher prevalence of preoperative anemia. This information can identify the institutions in which preoperative anemia is a critical issue and in which new strategies, such as preoperative screening clinics, might be helpful.
ABSTRACT
Abstract Introduction Convalescent Plasma therapy is one of the therapeutic strategies that has been used for patients with the Covid-19 disease. Implementing a program with national extension to supply hospitals with this blood component is a great challenge mainly in a middle-income economy. Objectives Our objective was to develop and implement a Covid-19 Convalescent Plasma Program which met established quality standards and was adapted to a reality of limited resources. Methods A multicentric convalescent plasma collection program was developed and implemented, based on four main sequential procedures: selective donor recruitment, pre-donation antibody screening (Anti-SARS-CoV-2- Chemiluminescence IgG Abbott), convalescent plasma collection by apheresis or whole-blood processing and distribution to the hospitals according to local demand. Results From the 572 candidates submitted to the pre-donation antibody screening, only 270 (47%) were considered eligible for plasma donation according to the established criteria. Higher levels of total antibody were associated with the donor age being above 45 years old (p= 0.002), hospital admission (p= 0.018), and a shorter interval between the diagnosis of the SARS-CoV-2 infection and plasma donation (p < 0.001). There was no association between the ABO and Rh blood groups and their antibody levels. Of the 468 donations made, 61% were from the collection of whole-blood and 39%, from apheresis. The Covid-19 Convalescent Plasma units obtained were distributed to 21 different cities throughout the country by air or ground transportation. Conclusion The implementation of a Covid-19 Convalescent Plasma program in a continental country with relatively scarce resources is feasible with alternative strategies to promote lower cost procedures, while complying with local regulations and meeting quality standards.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Young Adult , Blood Component Removal , Immunization, Passive , COVID-19/therapy , Plasma , SARS-CoV-2ABSTRACT
Os hemocentros têm como missão o cuidado com a qualidade dos hemoderivados sangüíneos, desde o recrutamento dos doadores até sua análise imunoematológica e sua distribuição. O Banco de Sangue de Caxias do Sul, principal hemocentro da região nordeste do Rio Grande do Sul, fornece 12.500 bolsas de sangue ao ano para os hospitais da própria região e regiões vizinhas. Este trabalho teve como objetivo determinar a prevalência, no Banco de Sangue de Caxias do Sul, dos marcadores sorológicos das principais doenças infecto-contagiosas transmissíveis por transfusão, relacionando-os com as variáveis sexo, faixa etária e nível de escolaridade. O estudo caracterizou-se como transversal histórico, sendo realizado através dos registros dos pacientes no período de janeiro de 2001 a junho de 2005. A faixa etária do sexo masculino foi de 37 ± 10 anos e do sexo feminino foi 38 ± 11 anos. O marcador de maior prevalência durante o período estudado foi o anti-HBc (1,67%), seguido do marcador VDRL (0,65%), HBsAg (0,18%), anti-HCV (0,12%), Chagas (0,06%), anti-HIV (0,05%) e anti-HTLV (0,02%). Apesar do número de pessoas doadoras de sangue aumentar anualmente, a taxa de descarte de bolsas de sangue na cidade de Caxias do Sul e no Brasil tem diminuído. Os resultados desse estudo refletem a importância das campanhas de conscientização sobre as doenças sexualmente transmissíveis e as medidas de segurança transfusional tomadas pelos hemocentros.